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HelpTest Code 21OH 21-Hydroxylase Antibodies, Serum
Additional Codes
CNE Order Code: 21 Hydroxylase
Ordering Guidance
Testing for autoantibodies against 21-hydroxylase is recommended following confirmation of adrenal insufficiency to help differentiate between causes of primary adrenal insufficiency
Shipping Instructions
Ship specimen frozen on dry ice
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial to remove from cells or gel prior to shipping.
Useful For
Investigating adrenal insufficiency
Aiding in the detection of those at risk of developing autoimmune adrenal failure in the future
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Reporting Name
21-Hydroxylase Ab, SSpecimen Type
SerumSpecimen Minimum Volume
0.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
Negative
Interpretation
This is a qualitative test. A positive result indicates the presence of autoantibodies to 21-hydroxylase and is consistent with Addison disease.
Utilizing an index value of <45 as a negative cutoff, this assay has a clinical sensitivity and specificity of 87.0% (95% CI: 79.4%-92.2%) and 99.3% (95% CI: 97.5%-99.8%), respectively.
Day(s) Performed
Wednesday
Report Available
3 to 9 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83516
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| 21OH | 21-Hydroxylase Ab, S | 85363-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 607788 | 21-Hydroxylase Ab, S | 85363-0 |