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HelpTest Code ADVQU Adenovirus DNA Detection and Quantification, Plasma
Ordering Guidance
Request this test only in at-risk individuals, such as organ or hematopoietic stem cell transplant recipients, suspected of developing disseminated adenoviral infection.
Shipping Instructions
1. Ship specimen frozen on dry ice only.
2. If shipment will be delayed for more than 24 hours, freeze plasma at -20 to -80° C (up to 30 days) until transport and ship on dry ice.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.5 mL (plasma)
Collection Instructions:
1. Centrifuge blood collection tube per manufacturer's instructions (eg, centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes).
2. Aliquot plasma into plastic vial.
Useful For
Aiding in the diagnosis of disseminated adenovirus infections in at-risk individuals
Measuring adenoviral load in plasma to monitor disease progression and antiviral response in individuals with disseminated infection
Method Name
Real-Time (Quantitative) Polymerase Chain Reaction (rt-qPCR)
Reporting Name
Adenovirus DNA Detect/Quant, PSpecimen Type
Plasma EDTASpecimen Minimum Volume
0.8 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma EDTA | Frozen (preferred) | 30 days |
| Refrigerated | 6 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
Undetected
Interpretation
The quantification range of this assay is 30 to 10,000,000 IU/mL (1.48 log to 7.00 log IU/mL), with a limit of detection (at 95% detection rate) at 30 IU/mL.
An "Undetected" result indicates that ADV DNA is not detected in the plasma specimen (see Cautions). In at-risk individuals, follow-up serial weekly testing is recommended.
A result of "<30 IU/mL" indicates that the ADV DNA level present in the plasma specimen is below 30 IU/mL (1.48 log IU/mL), and the assay cannot accurately quantify the ADV DNA present below this level.
A quantitative value (reported in IU/mL and log IU/mL) indicates the ADV DNA level (ie, viral load) present in the plasma specimen.
A result of ">10,000,000 IU/mL" indicates that the ADV DNA level present in the plasma specimen is above 10,000,000 IU/mL (7.00 log IU/mL), and this assay cannot accurately quantify the ADV DNA present above this level.
An "Inconclusive" result indicates that the presence or absence of ADV DNA in the plasma specimen could not be determined with certainty after repeat testing in the laboratory, possibly due to polymerase chain reaction inhibition or presence of interfering substance. Submission of a new specimen for testing is recommended if clinically indicated.
Day(s) Performed
Tuesday, Friday
Report Available
1 to 4 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
87799
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ADVQU | Adenovirus DNA Detect/Quant, P | 106727-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 622150 | Adenovirus DNA Detect/Quant, P | 106727-1 |
Forms
If not ordering electronically, complete, print, and send an Microbiology Test Request (T244) with the specimen.