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Test Code AHDV Hepatitis D Virus (HDV) Total Antibodies with Reflex to HDV RNA Detection and Quantitation, PCR, Serum

Additional Codes

CNE Order Code: HepD Ab


Necessary Information


Date of collection is required.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions:

1. Centrifuge blood collection tube per collection tube manufacturer's instructions (eg, centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes).

2. Aliquot serum into plastic vial.


Useful For

Detection of hepatitis D virus (HDV)-specific total antibodies (combined IgG and IgM) in human serum

 

Diagnosis of concurrent HDV infection in patients with fulminant acute hepatitis B virus (HBV) infection (acute coinfection), chronic hepatitis B (chronic coinfection), or acute exacerbation of known chronic hepatitis B (HDV superinfection)

Method Name

Enzyme Immunoassay (EIA)

Reporting Name

HDV Total Ab + reflex to HDV RNA, S

Specimen Type

Serum

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 30 days
  Refrigerated  5 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Negative

Interpretation

This assay detects the presence of hepatitis D virus (HDV)-specific total (combined IgG and IgM) antibodies in serum.

 

Negative results indicate the absence of HDV infection and no past exposure to HDV.

 

Equivocal results indicate borderline level of anti-HDV total antibodies. Repeat testing in 1 to 2 weeks is recommended to determine the definitive HDV infection status.

 

Positive results usually indicate simultaneous acute or chronic coinfection with hepatitis B virus (HBV) and HDV; acute HDV infection in patients with known chronic HBV infection (ie, HDV superinfection); or resolved HDV infection. All such antibody-positive specimens will automatically reflex to HDV RNA testing. Results should be correlated with medical history and clinical findings.

Day(s) Performed

Monday, Friday

Report Available

1 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86692

87523 if needed

LOINC Code Information

Test ID Test Order Name Order LOINC Value
AHDV HDV Total Ab + reflex to HDV RNA, S 40727-0

 

Result ID Test Result Name Result LOINC Value
9209 HDV Total Ab, S 40727-0

Forms

If not ordering electronically, complete, print, and send 1 of the following:

-Kidney Transplant Test Request

-Gastroenterology and Hepatology Test Request (T728)

-Infectious Disease Serology Test Request (T916)

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HDVQU HDV RNA Detect / Quant, S Yes No

Testing Algorithm

This test begins with hepatitis D virus (HDV) total antibodies by enzyme immunoassay. If the result is equivocal or positive, then HDV RNA detection/quantification will be performed at an additional charge.

 

For more information see Hepatitis D: Diagnostic Testing Algorithm.