Note

 Antibody results should not be used alone for diagnosis and must be interpreted in light of clinical manifestations and other test results.

M2 antibodies are significant for the clinical diagnosis of primary biliary cirrhosis (PBC).  Individuals who test positive for these antibodies, even in the absence of disease signs, are very likely to develop PBC.  Anti-M2 antibodies are present in approximately 95% of PBC-patients.