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Test Code ARBOP Arbovirus Antibody Panel, IgG and IgM, Serum

Useful For

Aiding the diagnosis of arboviral encephalitis (California [LaCrosse], St. Louis, Eastern equine, and Western equine encephalitis)

Profile Information

Test ID Reporting Name Available Separately Always Performed
CAVP Calif Virus (LaCrosse)IgG and IgM,S Yes Yes
EEEP East Equine Enceph Ab, IgG and IgM, S Yes Yes
STLP St. Louis Enceph Ab, IgG and IgM, S Yes Yes
WEEP West Equine Enceph Ab,IgG and IgM,S Yes Yes

Method Name

Immunofluorescence Assay (IFA)

Reporting Name

Arbovirus Ab Panel IgG and IgM, S

Specimen Type

Serum


Ordering Guidance


This panel tests for 4 arboviruses; to test for a specific arbovirus, the following tests are individually orderable:

-CAVP / California Virus (La Crosse) IgG and IgM, Serum

-EEEP / Eastern Equine Encephalitis Antibody, IgG and IgM, Serum

-STLP / St. Louis Encephalitis Antibody, IgG and IgM, Serum

-WEEP / Western Equine Encephalitis Antibody, IgG and IgM, Serum



Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

0.15 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Reference Values

CALIFORNIA VIRUS (La CROSSE) ENCEPHALITIS ANTIBODY

IgG: <1:10

IgM: <1:10 

Reference values apply to all ages.

 

EASTERN EQUINE ENCEPHALITIS ANTIBODY

IgG: <1:10

IgM: <1:10 

Reference values apply to all ages.

 

ST. LOUIS ENCEPHALITIS ANTIBODY

IgG: <1:10

IgM: <1:10 

Reference values apply to all ages.

 

WESTERN EQUINE ENCEPHALITIS

IgG: <1:10

IgM: <1:10 

Reference values apply to all ages.

Interpretation

In patients infected with these or related viruses, IgM class antibody is reliably detected within 1 to 3 weeks of onset, peaking and rapidly declining within 3 months. Results from a single serum specimen can differentiate early (acute) infection from past infection with immunity if IgM is positive (suggests acute infection).

 

IgG antibody is generally detectable within 1 to 3 weeks of onset, peaking within 1 to 2 months, and declining slowly thereafter. A single serum specimen IgG of 1:10 or greater indicates exposure to the virus. A 4-fold or greater rise in IgG antibody titer in acute and convalescent sera indicates recent infection.

 

In the United States, it is unusual for any patient to show positive reactions to more than 1 of the arboviral antigens, although Western equine encephalitis and Eastern equine encephalitis antigens will show a noticeable cross-reactivity.

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86651 x 2-California virus (La Crosse) encephalitis antibody, IgG and IgM

86652 x 2-Eastern equine encephalitis antibody, IgG and IgM

86653 x 2-St. Louis encephalitis antibody, IgG and IgM

86654 x 2-Western equine encephalitis antibody, IgG and IgM

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ARBOP Arbovirus Ab Panel IgG and IgM, S 49093-8

 

Result ID Test Result Name Result LOINC Value
8764 Calif (LaCrosse) Encep Ab, IgG, S In Process
83354 East Equine Enceph Ab, IgG, S In Process
8182 St. Louis Enceph Ab, IgG, S In Process
8193 West Equine Enceph Ab, IgG, S 6957-5
87279 West Equine Enceph Ab, IgM, S In Process
87268 St. Louis Enceph Ab, IgM, S In Process
83355 East Equine Enceph Ab, IgM, S In Process
87280 Calif (LaCrosse) Encep Ab, IgM, S In Process

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Testing Algorithm

The following algorithms are available:

-Meningitis/Encephalitis Panel Algorithm

-Mosquito-borne Disease Laboratory Testing