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HelpTest Code CATTR Cold Agglutinin Titer, Serum
Ordering Guidance
The cold agglutinin test is not specific for Mycoplasma pneumoniae and is not recommended to diagnose M pneumoniae infections. To diagnose M pneumoniae infections, order MPRP / Mycoplasmoides pneumoniae, Molecular Detection, PCR, Varies. For screening recent or past exposure to M pneumoniae, order MYCO / Mycoplasma pneumoniae Antibodies, IgG and IgM, Serum.
Specimen Required
Collection Container/Tube: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 4 mL
Pediatric Volume: 1 mL
Collections Instructions:
1. Use a warm pack to keep specimen at 37° C prior to and after collecting.
2. Allow specimen to clot at 37° C.
3. Centrifuge at 37° C and aliquot serum into plastic vial immediately after blood clots or within one hour of collection.
4. Do not refrigerate prior to separation of serum from red cells.
Useful For
Detection of cold agglutinins in patients with suspected cold agglutinin disease
This test is not recommended to diagnose Mycoplasma pneumoniae infections.
Method Name
Titration/Red Cell Agglutination
Reporting Name
Cold Agglutinin TiterSpecimen Type
Serum RedSpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 7 days | |
| Frozen | 7 days | ||
| Ambient | 72 hours |
Reject Due To
| Gross hemolysis | OK |
| Gross icterus | OK |
Reference Values
Titer results:
>64: Elevated
>1000: May be indicative of hemolytic anemia
Interpretation
Titers above 64 are considered elevated, but hemolytic anemia resulting from cold-reactive autoagglutinins rarely occurs unless the titer is 1000 or above. Titers below 1000 may be obtained when the autoantibody has a different specificity (eg, anti-i) or if the cold agglutinin is of the less-common low-titer, high-thermal-amplitude type.
The test is not a direct measure of clinical significance and must be used in conjunction with other in vitro and in vivo parameters.
Day(s) Performed
Monday through Friday, Sunday
Report Available
1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
86157
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CATTR | Cold Agglutinin Titer | 14658-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CATTR | Cold Agglutinin Titer | In Process |
Forms
If not ordering electronically, complete, print, and send an Benign Hematology Test Request (T755) with the specimen.