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Test Code CAVP California Virus (La Crosse) IgG and IgM, Serum

Useful For

Aiding the diagnosis of California (La Crosse) encephalitis using serum specimens

Method Name

Immunofluorescence Assay (IFA)

Reporting Name

Calif Virus (LaCrosse)IgG and IgM,S

Specimen Type

Serum


Ordering Guidance


This assay detects only California virus. For a complete arbovirus panel, order ARBOP / Arbovirus Antibody Panel, IgG and IgM, Serum.



Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

0.15 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Reference Values

IgG: <1:10

IgM: <1:10

Reference values apply to all ages.

Interpretation

In patients infected with these or related viruses, IgG antibody is generally detectable within 1 to 3 weeks of onset, peaking within 1 to 2 months and declining slowly thereafter.

 

IgM class antibody is also reliably detected within 1 to 3 weeks of onset, peaking and rapidly declining within 3 months.

 

Single serum specimen IgG of 1:10 or greater indicates exposure to the virus.

 

Results from a single serum specimen can differentiate early (acute) infection from past infection with immunity if IgM is positive (suggests acute infection).

 

A 4-fold or greater rise in IgG antibody titer in acute and convalescent sera indicates recent infection.

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86651 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CAVP Calif Virus (LaCrosse)IgG and IgM,S 96499-9

 

Result ID Test Result Name Result LOINC Value
8764 Calif (LaCrosse) Encep Ab, IgG, S In Process
87280 Calif (LaCrosse) Encep Ab, IgM, S In Process

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Testing Algorithm

For more information see Mosquito-borne Disease Laboratory Testing.