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Test Code CHIKV Chikungunya IgM and IgG, Antibody, Serum

Useful For

Aiding in the diagnosis of recent infection with Chikungunya virus in patients with recent travel to endemic areas and a compatible clinical syndrome

Profile Information

Test ID Reporting Name Available Separately Always Performed
CHIKM Chikungunya IgM, Ab, S No Yes
CHIKG Chikungunya IgG, Ab, S No Yes
CHIKI Chikungunya Interpretation No Yes

Method Name

CHIKM, CHIKG: Enzyme-Linked Immunosorbent Assay (ELISA)

CHIKI: Technical Interpretation

Reporting Name

Chikungunya IgM and IgG, Ab, S

Specimen Type

Serum


Ordering Guidance


Testing a patient in a convalescent period is recommended because specimens collected too early following infection may be negative for antibodies to Chikungunya virus.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL Serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

Serum: 0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 30 days
  Frozen  30 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

IgM: Negative

IgG: Negative

Reference values apply to all ages.

Interpretation

IgM and IgG Negative:

No serologic evidence of exposure to Chikungunya virus. Repeat testing on a new specimen collected in 5 to 10 days is recommended if clinical suspicion persists.

 

IgM and IgG Positive:

IgM and IgG antibodies to Chikungunya virus detected, suggesting recent or past infection. Correlate with exposure history and clinical presentation. Confirmatory testing at a public health lab is suggested. IgM antibodies to Chikungunya virus may remain detectable for 3 to 4 months post-infection.

 

IgM Positive, IgG Negative:

IgM antibodies to Chikungunya virus detected, suggesting recent infection. Correlate with exposure history and clinical presentation. Confirmatory testing at a public health lab is suggested. Repeat testing in 5 to 10 days is recommended to demonstrate anti-Chikungunya virus IgG seroconversion to confirm current infection.

 

IgM Negative, IgG Positive:

IgG antibodies to Chikungunya virus detected, suggesting past infection.

 

IgM and/or IgG Borderline:

Repeat testing in 10 to 14 days is recommended.

Day(s) Performed

Bimonthly on the second and fourth Wednesday; fifth Wednesday when applicable

Report Available

Same day/1 to 14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86790 x2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CHIKV Chikungunya IgM and IgG, Ab, S 93976-9

 

Result ID Test Result Name Result LOINC Value
CHIKI Chikungunya Interpretation 69048-7
CHIKG Chikungunya IgG, Ab, S 88630-9
CHIKM Chikungunya IgM, Ab, S 88629-1

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Testing Algorithm

For information see Mosquito-borne Disease Laboratory Testing.