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HelpTest Code CLOBZ Clobazam and Metabolite, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Collect blood immediately before next scheduled dose.
2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Additional Information: Trough specimens are recommended as therapeutic ranges are based on specimens collected at trough (ie, immediately before the next dose).
Useful For
Monitoring clobazam therapy
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Clobazam and metabolite, SSpecimen Type
Serum RedSpecimen Minimum Volume
0.35 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Clobazam
Therapeutic Range: 30-300 ng/mL
N-desmethylclobazam (Norclobazam)
Therapeutic Range: 300-3,000 ng/mL
Interpretation
The results of this test should be interpreted in conjunction with the patient's physical signs, symptoms, and other laboratory test results.
Most individuals display optimal response to clobazam when serum levels of clobazam are between 30 and 300 ng/mL and N-desmethylclobazam are between 300 and 3000 ng/mL. Risk of toxicity is increased when clobazam levels are above 500 ng/mL or N-desmethlyclobazam levels are above 5000 ng/mL.
Some individuals may respond well outside of these ranges or may display toxicity within the therapeutic range; thus, interpretation should include clinical evaluation.
Day(s) Performed
Monday through Friday
Report Available
Same day/1 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
80339 (G0480 if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CLOBZ | Clobazam and metabolite, S | 79408-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 65483 | Clobazam | 3487-6 |
| 92363 | N-desmethylclobazam | 35107-2 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.