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HelpTest Code CLZ Clozapine, Serum
Additional Codes
CNE Order Code: Clozapine
Useful For
Monitoring patient compliance of clozapine treatment
An aid to achieving desired serum levels
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Clozapine, SSpecimen Type
Serum RedOrdering Guidance
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Â
1. Collect specimen immediately before next scheduled dose.
2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Additional Information: Therapeutic range (trough level) applies to specimens collected immediately prior to next dose.
Specimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Clozapine
Therapeutic range: 350-600 ng/mL
Norclozapine
Therapeutic range: Not well established
Clozapine + Norclozapine
Therapeutic range: Not well established
Interpretation
The effectiveness of clozapine treatment should be based on clinical response and treatment should be discontinued in patients failing to show an acceptable clinical response.
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
80159
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CLZ | Clozapine, S | 65632-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 33840 | Clozapine | 6896-5 |
| 33841 | Norclozapine | 10992-6 |
| 33842 | Clozapine+Norclozapine Total | 12375-2 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.