Test Code COM Complement, Total, Serum
Additional Codes
CNE Order Code: Complement-T
Reporting Name
Complement, Total, SUseful For
Detection of individuals with an ongoing immune process
First-tier screening test for congenital complement deficiencies
Performing Laboratory

Specimen Type
SerumSpecimen Required
Patient Preparation: Fasting preferred but not required
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Immediately after specimen collection, place the tube on wet ice and allow specimen to clot.
2. Centrifuge at 4° C and aliquot serum into 5 mL plastic vial.
3. Within 30 minutes of centrifugation, freeze specimen. Specimen must be placed on dry ice if not frozen immediately.
NOTE: If a refrigerated centrifuge is not available, it is acceptable to use a room temperature centrifuge, provided the specimen is kept on ice before centrifugation, and immediately afterward, the serum is aliquoted and frozen.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
Specimen Type | Temperature | Time |
---|---|---|
Serum | Frozen | 28 days |
Reference Values
30-75 U/mL
Day(s) Performed
Monday through Friday
CPT Code Information
86162
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
COM | Complement, Total, S | 4532-8 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
COM | Complement, Total, S | 4532-8 |
Interpretation
Low levels of total complement (total hemolytic complement) may occur during infections, disease exacerbation in patients with systemic lupus erythematosus, and in patients with immune complex diseases such as glomerulonephritis.
Undetectable levels suggest the possibility of a complement component deficiency. Individual complement component assays are useful to identify the specific deficiency.
Report Available
1 to 2 daysReject Due To
Gross hemolysis | OK |
Gross lipemia | OK |
Gross icterus | OK |
Method Name
Automated Liposome Lysis Assay