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HelpTest Code EBVAB Epstein-Barr Virus Antibody Profile, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Diagnosis of Epstein-Barr virus (EBV) infectious mononucleosis or other EBV related infections
Identification of prior EBV infection as part of pre-immunosuppression screening
This assay is not intended for viral isolation or identification.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| MEBV | EBV VCA IgM, S | No | Yes |
| GEBV | EBV VCA IgG, S | No | Yes |
| NAEBV | EBV NA IgG, S | No | Yes |
| INTEB | Interpretation | No | Yes |
Method Name
MEBV, GEBV, NAEBV: Enzyme-Linked Immunosorbent Assay (ELISA)
INTEB: Technical Interpretation
Reporting Name
EBV Ab Profile, SSpecimen Type
SerumSpecimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Frozen (preferred) | 14 days | |
| Refrigerated | 48 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
| Heat-inactivated specimen | Reject |
Reference Values
Epstein-Barr Virus VIRAL CAPSID ANTIGEN (VCA) IgM ANTIBODY:
Negative
Epstein-Barr Virus VIRAL CAPSID ANTIGEN (VCA) IgG ANTIBODY:
Negative
EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN (EBNA) IgG ANTIBODY:
Negative
Interpretation
The profile has 3 components: viral capsid antigen (VCA) IgG, VCA IgM, and Epstein-Barr nuclear antigen (EBNA).
Presence of VCA IgM antibodies suggests an acute or recent primary infection with Epstein-Barr virus (EBV).
Presence of VCA IgG antibodies indicates infection sometime in the recent or remote past.
Antibodies to EBNA develop 6 to 8 weeks after primary infection and are detectable for life.
Refer to table below for interpretation of EBV antibody results.
|
VCA IgM result |
VCA IgG result |
EBNA IgG result |
Interpretation |
|
Negative |
Positive |
Negative |
Results suggest recent EBV infection. The detection of only anti-VCA IgG should be interpreted with caution in immunocompromised patients, as this population may demonstrate diminishing or undetectable levels of anti-EBNA IgG antibodies. |
|
Positive |
Positive |
Negative |
Results suggest recent EBV infection. |
|
Positive |
Negative |
Negative |
|
|
Positive |
Equivocal |
Equivocal |
Results suggest recent EBV infection. Recommend follow-up testing in 10-14 days if clinically indicated. |
|
Positive |
Equivocal |
Negative |
|
|
Positive |
Positive |
Equivocal |
|
|
Positive |
Negative |
Equivocal |
|
|
Positive |
Positive |
Positive |
Results may suggest recent EBV recovery or reactivation. |
|
Positive |
Equivocal |
Positive |
|
|
Positive |
Negative |
Positive |
|
|
Negative |
Negative |
Negative |
Results suggest no prior exposure to EBV. However, a second serum specimen should be tested in 10-14 days if clinically indicated. |
|
Negative |
Positive |
Positive |
Results suggest past EBV infection. |
|
Negative |
Negative |
Positive |
|
|
Negative |
Equivocal |
Positive |
|
|
Negative |
Positive |
Equivocal |
Detection of anti-VCA IgG only should be interpreted with caution in immunocompromised patients, as this population may demonstrate diminishing or undetectable levels of anti-EBNA IgG antibodies. Recommend follow-up testing in 10-14 days if clinically indicated. |
|
Equivocal |
Negative |
Positive |
Results suggest past EBV infection. Recommend follow-up testing in 10-14 days if clinically indicated. |
|
Equivocal |
Equivocal |
Positive |
|
|
|
|
|
Results with unclear clinical significance |
|
Negative |
Negative |
Equivocal |
Recommend follow-up testing in 10-14 days if clinically indicated. |
|
Negative |
Equivocal |
Negative |
|
|
Negative |
Equivocal |
Equivocal |
|
|
Equivocal |
Negative |
Negative |
|
|
Equivocal |
Negative |
Equivocal |
|
|
Equivocal |
Equivocal |
Negative |
|
|
Equivocal |
Equivocal |
Equivocal |
|
|
Equivocal |
Positive |
Negative |
|
|
Equivocal |
Positive |
Equivocal |
|
|
Equivocal |
Positive |
Positive |
Day(s) Performed
Monday through Friday
Report Available
Same day/1 to 2 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
86664-EBNA
86665 x 2-VCA, IgG and IgM
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| EBVAB | EBV Ab Profile, S | 87554-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| GEBV | EBV VCA IgG, S | 24114-1 |
| INTEB | Interpretation | 69048-7 |
| MEBV | EBV VCA IgM, S | 24115-8 |
| NAEBV | EBV NA IgG, S | 5156-5 |