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HelpTest Code EDN Eosinophil Derived Neurotoxin, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial within 12 hours of collection. Serum cannot sit on either gel or cells for longer than 12 hours.
Useful For
Evaluating patients suspected to have a condition associated with eosinophilia or hypereosinophilia
Evaluating patients with elevated peripheral blood eosinophil counts
Managing patients with elevated eosinophil-derived neurotoxin in the context of eosinophil-associated diseases
Method Name
Fluorescence Enzyme Immunoassay (FEIA)
Reporting Name
Eosinophil Derived Neurotoxin, SSpecimen Type
SerumSpecimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 21 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
| Heat-treated specimen | Reject |
| If serum is on cell pellet or gel for >12 hours | Reject |
Reference Values
<70 mcg/L: Normal
70-99 mcg/L: Borderline
≥100 mcg/L: Elevated
Reference values apply to all ages.
Interpretation
Eosinophil-derived neurotoxin (EDN) concentrations greater than or equal to 100 mcg/L, in the presence of elevated numbers of peripheral blood or tissue-resident eosinophils, may be suggestive of inflammation or increased disease activity in patients with eosinophil-associated diseases.
In the context of normal eosinophil counts, EDN concentrations greater than 70 mcg/L may indicate cellular activation and degranulation.
In the context of elevated eosinophil counts, EDN concentrations less than or equal to 70 mcg/L may indicate limited or absent cellular activation.
Day(s) Performed
Tuesday
Report Available
2 to 8 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83520
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| EDN | Eosinophil Derived Neurotoxin, S | 100976-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| EDN | Eosinophil Derived Neurotoxin, S | 100976-0 |