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HelpTest Code EEEV1 Red Blood Cell (RBC) Enzyme Evaluation, Blood
Necessary Information
Metabolic Hematology Patient Information (T810) is strongly recommended and should include clinical history. Testing may proceed without this information, however if the information requested is received, it allows for a more complete interpretation.
Specimen Required
Container/Tube:
Preferred: Yellow top (ACD solution B)
Acceptable: Yellow top (ACD solution A)
Specimen Volume: 12 mL
Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.
Forms
1. Metabolic Hematology Patient Information (T810)
2. If not ordering electronically, complete, print, and send a Benign Hematology Test Request (T755) with the specimen.
Useful For
Identifying defects of red blood cell enzyme metabolism
Evaluating patients with Coombs-negative hemolytic anemia
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| EEEVI | Erythrocyte Enzyme Interpretation | No | Yes |
| G6PDC | G6PD Enzyme Activity, B | Yes, (Order G6PD1) | Yes |
| PKC | PK Enzyme Activity, B | Yes, (Order PK1) | Yes |
| GPIC | Glucose Phosphate Isomerase, B | Yes, (Order GPI1) | Yes |
| HKC | Hexokinase, B | Yes, (Order HK1) | Yes |
| AKC | Adenylate Kinase, B | Yes, (Order AK1) | Yes |
| PFKC | Phosphofructokinase, B | Yes, (Order PFK1) | Yes |
| PGKC | Phosphoglycerate Kinase, B | Yes, (Order PGK1) | Yes |
| TPIC | Triosephosphate Isomerase, B | Yes, (Order TPI1) | Yes |
| GSH | Glutathione, B | Yes | Yes |
| P5NT | Pyrimidine 5' Nucleotidase, B | Yes | Yes |
Testing Algorithm
This is a consultative evaluation in which the case will be evaluated at Mayo Clinic Laboratories.
Special Instructions
Method Name
EEEVI: Medical Interpretation
G6PDC, GPIC, PKC, HKC, AKC, PFKC, PGKC, TPIC, GSH, P5NT: Kinetic Spectrophotometry
Reporting Name
RBC Enzyme EvaluationSpecimen Type
Whole Blood ACD-BSpecimen Minimum Volume
5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood ACD-B | Refrigerated | 11 days |
Reject Due To
| Gross hemolysis | Reject |
Reference Values
Definitive results and an interpretive report will be provided.
Interpretation
A hematopathologist expert in these disorders evaluates the case, and an interpretive report is issued.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82955-G6PD Enzyme Activity
84087-Glucose phosphate isomerase
84220-Pyruvate Kinase Enzyme Activity
82657-Hexokinase
82657-Adenylate Kinase
82657-Phosphofructokinase
82657-Phosphoglycerate Kinase
82657-Triosephosphate Isomerase
82978-Glutathione
83915-Pyrimidine 5' Nucleotidase
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| EEEV1 | RBC Enzyme Evaluation | 72695-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| PKCL | PK Enzyme Activity, B | 32552-2 |
| GPICL | Glucose Phosphate Isomerase, B | 44050-3 |
| G6PCL | G6PD Enzyme Activity, B | 32546-4 |
| 608409 | Glutathione, B | 2383-8 |
| TPICL | Triosephosphate Isomerase, B | 44054-5 |
| PGKCL | Phosphoglycerate Kinase, B | 44053-7 |
| PFKCL | Phosphofructokinase, B | 72664-6 |
| HKCL | Hexokinase, B | 49216-5 |
| 2734 | Pyrimidine 5' Nucleotidase, B | 2902-5 |
| AKCL | Adenylate Kinase, B | 44051-1 |
| 608087 | Erythrocyte Enzyme Interpretation | 59466-3 |
| 608109 | Reviewed By | 18771-6 |
Day(s) Performed
Tuesday, Thursday