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HelpTest Code FLUOX Fluoxetine, Serum
Additional Codes
CNE Order Code: Fluoxetine
Reporting Name
Fluoxetine, SUseful For
Monitoring serum concentration of fluoxetine during therapy
Evaluating potential toxicity
Evaluating patient compliance
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Draw blood immediately before the next scheduled dose (trough).
2. Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 72 hours |
Reference Values
Fluoxetine + Norfluoxetine: 120-500 ng/mL
Day(s) Performed
Wednesday
CPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FLUOX | Fluoxetine, S | 78437-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 80228 | Fluoxetine, S | 74982-0 |
| 251 | Norfluoxetine, S | 3868-7 |
| 252 | Fluoxetine+Norfluoxetine | 74948-1 |
Interpretation
Most individuals display optimal response to fluoxetine when combined serum levels of fluoxetine and norfluoxetine are between 120 and 500 ng/mL. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; therefore, interpretation should include clinical evaluation. A toxic range has not been well established.
Report Available
1 to 8 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.