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Test Code FLUOX Fluoxetine, Serum

Additional Codes

CNE Order Code: Fluoxetine

Reporting Name

Fluoxetine, S

Useful For

Monitoring serum concentration of fluoxetine during therapy

 

Evaluating potential toxicity

 

Evaluating patient compliance

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum Red


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL Serum

Collection Instructions:

1. Draw blood immediately before the next scheduled dose (trough).

2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

Fluoxetine + Norfluoxetine: 120-500 ng/mL

Day(s) Performed

Wednesday

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FLUOX Fluoxetine, S 78437-1

 

Result ID Test Result Name Result LOINC Value
80228 Fluoxetine, S 74982-0
251 Norfluoxetine, S 3868-7
252 Fluoxetine+Norfluoxetine 74948-1

Interpretation

Most individuals display optimal response to fluoxetine when combined serum levels of fluoxetine and norfluoxetine are between 120 and 500 ng/mL. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; therefore, interpretation should include clinical evaluation. A toxic range has not been well established.

Report Available

1 to 8 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.