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HelpTest Code HCQWB Hydroxychloroquine, Blood
Specimen Required
Container/Tube: Lavender top (EDTA)
Specimen Volume: 1 mL
Collection Instructions:
1. Collect specimen immediately before next scheduled dose.
2. Send whole blood specimen in original tube. Do not aliquot.
Useful For
Monitoring whole blood hydroxychloroquine concentrations, assessing compliance, and adjusting dosage in patients
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Hydroxychloroquine, BSpecimen Type
Whole Blood EDTASpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood EDTA | Refrigerated (preferred) | 28 days |
| Ambient | 28 days | |
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
| Clotted specimens | Reject |
Reference Values
≥200 ng/mL
Interpretation
For systemic lupus erythematosus, therapeutic target whole blood concentrations of hydroxychloroquine of 1000-2000 ng/mL have been proposed.(1-3)
An effective therapeutic reference range of whole blood hydroxychloroquine concentrations of 750 to 1200 ng/mL was associated with 71% lower odds of active lupus and maintaining levels within this range reduced odds of flares by 26%.(4)
Whole blood hydroxychloroquine concentrations below 200 ng/mL denote noncompliance and risk of flare in lupus.(1) Concentrations of 500 ng/mL or higher are consistent with adherence.(2) Whole blood hydroxychloroquine monitoring is more stable, precise, and better correlated to efficacy than serum/plasma concentrations.(5)
Day(s) Performed
Tuesday, Thursday
Report Available
3 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
80220
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HCQWB | Hydroxychloroquine, B | 95921-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 623295 | Hydroxychloroquine, B | 95921-3 |