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Test Code HISER Histoplasma Antibody Complement Fixation and Immunodiffusion, Serum


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.1 mL Serum

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Useful For

Aiding in the diagnosis of active histoplasmosis

Testing Algorithm

For more information see Meningitis/Encephalitis Panel Algorithm.

Method Name

Complement Fixation (CF)/Immunodiffusion (ID)

Reporting Name

Histoplasma Ab CompFix/ImmDiff, S

Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.6 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Reference Values

Anti-Yeast Antibody by Complement Fixation:

Negative (positive results reported as titer)

 

Antibody by Immunodiffusion:

Negative (positive results reported as band present)

Interpretation

Complement fixation (CF) titer results of 1:32 or higher indicate active disease. A rising CF titer is associated with progressive infection.

 

Patients infected with Histoplasma capsulatum demonstrate a serum antibody with a rising titer within 6 weeks of infection. A rising titer is associated with progressive infection. Specific antibody persists for a few weeks to a year, regardless of clinical improvement.

 

The presence of H and/or M bands on immunodiffusion tests is considered a positive result for the presence of antibodies to Histoplasma. Presence of an H band suggests recent infection.

Day(s) Performed

Monday through Friday

Report Available

2 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86698 x2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HISER Histoplasma Ab CompFix/ImmDiff, S 90227-0

 

Result ID Test Result Name Result LOINC Value
621214 Histoplasma Yeast CompFix, S 20574-0
621215 Histoplasma Immunodiffusion, S 90232-0

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Kidney Transplant Test Request

-Infectious Disease Serology Test Request (T916)