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HelpTest Code HISER Histoplasma Antibody Complement Fixation and Immunodiffusion, Serum
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Useful For
Aiding in the diagnosis of active histoplasmosis
Testing Algorithm
For more information see Meningitis/Encephalitis Panel Algorithm.
Special Instructions
Method Name
Complement Fixation (CF)/Immunodiffusion (ID)
Reporting Name
Histoplasma Ab CompFix/ImmDiff, SSpecimen Type
SerumSpecimen Minimum Volume
See Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
Reference Values
Anti-Yeast Antibody by Complement Fixation:
Negative (positive results reported as titer)
Antibody by Immunodiffusion:
Negative (positive results reported as band present)
Interpretation
Complement fixation (CF) titer results of 1:32 or higher indicate active disease. A rising CF titer is associated with progressive infection.
Patients infected with Histoplasma capsulatum demonstrate a serum antibody with a rising titer within 6 weeks of infection. A rising titer is associated with progressive infection. Specific antibody persists for a few weeks to a year, regardless of clinical improvement.
The presence of H and/or M bands on immunodiffusion tests is considered a positive result for the presence of antibodies to Histoplasma. Presence of an H band suggests recent infection.
Day(s) Performed
Monday through Friday
Report Available
2 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
86698 x2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HISER | Histoplasma Ab CompFix/ImmDiff, S | 90227-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 621214 | Histoplasma Yeast CompFix, S | 20574-0 |
| 621215 | Histoplasma Immunodiffusion, S | 90232-0 |