Test Code KCSFP Immunoglobulin Kappa Free Light Chain, Spinal Fluid
Ordering Guidance
For evaluation of multiple sclerosis, the following are available:
-SFIG / Cerebrospinal Fluid IgG Index Profile, Serum and Spinal Fluid
-OLIG / Oligoclonal Banding, Serum and Spinal Fluid
Specimen Required
Only orderable as part of a profile. For more information see MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid.
Specimen Type: Spinal fluid
Container/Tube: Sterile vial
Specimen Volume: 1 mL
Collection Instructions: Label specimen as spinal fluid.
Useful For
Diagnosis of multiple sclerosis and other demyelinating conditions
Method Name
Only orderable as part of a profile. For more information see MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid.
Nephelometry
Reporting Name
Kappa Free Light Chain, CSFSpecimen Type
CSFSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
CSF | Frozen (preferred) | 28 days | |
Refrigerated | 72 hours | ||
Ambient | 24 hours |
Reject Due To
Gross hemolysis | Reject |
Gross icterus | OK |
Reference Values
Only orderable as part of a profile. For more information see MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid.
Medical decision point: 0.1000 mg/dL
Interpretation
When result is greater than or equal to 0.1000 mg/dL, the kappa free light chain concentration measured in cerebrospinal fluid (CSF) is at or greater than the threshold associated with demyelinating disease. This is a positive result. These findings, however, are not specific for multiple sclerosis (MS) because CSF-specific immunoglobulin synthesis may also be detected in patients with other neurologic diseases (infectious, inflammatory, cerebrovascular, autoimmune, and paraneoplastic). Clinical correlation is recommended. Automatic reflexing to oligoclonal bands will occur.
When result is less than 0.0600 mg/dL, the kappa free light chain concentration measured in CSF is lower than the threshold associated with demyelinating disease. This is a negative result. Testing for oligoclonal banding is not performed. Clinical correlation is recommended.
When result is from 0.0600 to 0.0999 mg/dL, the kappa free light chain concentration measured in CSF is slightly elevated but not above the medical decision point of 0.1000 mg/dL associated with demyelinating disease. This is a borderline result. Reflexing to oligoclonal bands will be automatically performed and clinical correlation is recommended.
Day(s) Performed
Monday through Friday
Report Available
1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in RochesterCPT Code Information
83521
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
KCSFP | Kappa Free Light Chain, CSF | 48774-4 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
KCSFP | Kappa Free Light Chain, CSF | 48774-4 |