Interpretation

An interpretive report will be provided. The wild-type (normal) genotype for NAT2 is *4. This is the most commonly occurring allele in some, but not all, ethnic groups.(8)

Individuals are classified as being slow, intermediate, or rapid (fast) acetylators depending on their diplotypes. Slow acetylators have 2 slow haplotypes, rapid acetylators have 2 rapid (fast, normal) haplotypes, and intermediate acetylators have one of each.

The genotype, with associated star alleles, is assigned using standard allelic nomenclature as described by the Human NAT2 Alleles (Haplotypes) Database (http://nat.mbg.duth.gr/Human%20NAT2%20alleles_2013.htm).

For additional information regarding pharmacogenomic genes and their associated drugs, see Pharmacogenomic Associations Tables. This resource also includes information regarding enzyme inhibitors and inducers, as well as potential alternate drug choices.

Drug-drug interactions and drug-metabolite inhibition must be considered when adjusting medication dosage. It is important to interpret the results of testing and dose adjustments in the context of hepatic and renal function and patient age. For applicable medications, therapeutic drug monitoring is useful to verify that the drug concentration is within the therapeutic range.