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Test Code RO52 Ro52 Antibody, IgG, Serum


Ordering Guidance


This test detects antibodies to Ro52 only. For testing antibodies to both Ro 52 and Ro60, order ROPAN/Ro52 and Ro60 Antibodies, IgG, Serum.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial


Useful For

Evaluating patients at risk for connective tissue disease with or without interstitial lung disease

 

Differentiating single vs double positivity for Ro52 and Ro60 antibodies in combination with anti-Ro60

Method Name

Chemiluminescent Immunoassay

Reporting Name

Ro52 Antibody, IgG, S

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  21 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK

Reference Values

<20 CU (negative)

≥20 CU (positive)

Reference values apply to all ages

Interpretation

Results from this testing should be interpreted in the context of clinical findings and other laboratory testing. Tests cannot be exclusively relied upon to establish a diagnosis for any connective tissue disease or related disorder, including systemic lupus erythematosus, Sjogren's syndrome (SS), systemic sclerosis, or idiopathic inflammatory myopathy.

 

When assessed by standard SS-A (Ro) solid-phase immunoassays, such as enzyme immunoassays using combined antigens, some antibodies specific for either SSA 52 (Ro52) or SSA 60 (Ro60) may not be detected due to masking of target epitopes. In addition, multiplex bead assays with Ro52 or Ro60 antigens may simply be reported as SS-A/Ro positive without differentiation of the specific positive antibody.

Day(s) Performed

Wednesday

Report Available

2 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86235

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RO52 Ro52 Antibody, IgG, S 53017-0

 

Result ID Test Result Name Result LOINC Value
RO52 Ro52 Antibody, IgG, S 53017-0