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Test Code RO60 Ro60 Antibody, IgG, Serum


Ordering Guidance


This test detects antibodies to Ro60 only. For testing antibodies to both Ro 52 and Ro60, order ROPAN / Ro52 and Ro60 Antibodies, IgG, Serum.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial


Useful For

Evaluating patients at risk for connective tissue disease with or without interstitial lung disease

 

Differentiating single vs double positivity for Ro52 and Ro60 antibodies in combination with anti-Ro60

Method Name

Chemiluminescent Immunoassay

Reporting Name

Ro60 Antibody, IgG, S

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  21 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK

Reference Values

<20 CU (negative)

≥20 CU (positive)

Reference values apply to all ages

Interpretation

The presence of antibodies to both SSA 52 (Ro52) or SSA 60 (Ro60) is highly suggestive of a diagnosis of Sjogren syndrome (SS), with positivity for Ro60 alone more likely to be associated with systemic lupus erythematosus (SLE).

 

Antibodies to Ro52 may be present in patients with idiopathic inflammatory myopathy (IIM), systemic sclerosis (SSc), or overlap connective tissue disease (CTD). In CTD, antibodies to Ro52 alone or in association with other specific autoantibodies may be associated with interstitial lung diseases.

 

Negative results for antibodies to Ro52 and Ro60 does not exclude the possibility of any connective tissue disease, including SS, SLE, SSc, and IIM.

Day(s) Performed

Wednesday

Report Available

2 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86235

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RO60 Ro60 Antibody, IgG, S 53019-6

 

Result ID Test Result Name Result LOINC Value
RO60 Ro60 Antibody, IgG, S 53019-6