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HelpTest Code ROPAN Ro52 and Ro60 Antibodies, IgG, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial
Useful For
Evaluating patients at risk for connective tissue disease with or without interstitial lung disease
Differentiation of antibodies to Ro52 and Ro60 in patients known to be positive for anti-SS-A (Ro) antibodies
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| RO52 | Ro52 Antibody, IgG, S | Yes | Yes |
| RO60 | Ro60 Antibody, IgG, S | Yes | Yes |
Method Name
Chemiluminescent Immunoassay
Reporting Name
Ro52 and Ro60 Antibodies, IgG, SSpecimen Type
SerumSpecimen Minimum Volume
0.8 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 21 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
Ro52 ANTIBODY, IgG
<20 CU (negative)
≥20 CU (positive)
Reference values apply to all ages
Ro60 ANTIBODY, IgG
<20 CU (negative)
≥20 CU (positive)
Reference values apply to all ages
Interpretation
The presence of antibodies to both SS-A 52 (Ro52) or SSA 60 (Ro60) is highly suggestive of a diagnosis of Sjogren syndrome (SS), with positivity for Ro60 alone more likely to be associated with systemic lupus erythematosus (SLE).
Antibodies to Ro52 may be present in patients with idiopathic inflammatory myopathy (IIM), systemic sclerosis (SSc) or overlap connective tissue disease (CTD). In CTD, antibodies to Ro52 alone, or in association with other specific autoantibodies may be associated with interstitial lung diseases.
Negative results for antibodies to Ro52 and Ro60 does not exclude the possibility of any CTD, including SS, SLE, SSc, and IIM.
Day(s) Performed
Wednesday
Report Available
2 to 8 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
86235 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ROPAN | Ro52 and Ro60 Antibodies, IgG, S | 33610-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| RO52 | Ro52 Antibody, IgG, S | 53017-0 |
| RO60 | Ro60 Antibody, IgG, S | 53019-6 |