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Test Code SCOC Coccidioides Antibody, Complement Fixation and Immunodiffusion, Serum

Additional Codes

CNE Order Code: Coccidiomy ID

Reporting Name

Coccidioides Ab, CompF/ImmDiff, S

Useful For

Diagnosis of coccidioidomycosis using serum specimens

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Ordering Guidance


This test is a confirmatory assay for positive screening tests (ie, enzyme immunoassay).

 

The recommended test to evaluate for possible Coccidioides infection is COXIS / Coccidioides Antibody Screen with Reflex, Serum.



Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.8 mL Serum

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

Serum: 0.6 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

Complement Fixation: Negative

If positive, results are titered.

 

Immunodiffusion: Negative

Results are reported as positive, negative, or equivocal.

Day(s) Performed

Monday through Friday

CPT Code Information

86635 x 3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SCOC Coccidioides Ab, CompF/ImmDiff, S 87435-4

 

Result ID Test Result Name Result LOINC Value
8295 Coccidioides Ab, CompF, S In Process
21649 Coccidioides, IgG, ImmDiff, S 62459-3
21648 Coccidioides, IgM, ImmDiff, S 62458-5

Interpretation

Complement Fixation:

Titer results of 1:2 or higher may suggest active disease; however, titers may persist for months after infection has resolved. Increasing complement fixation (CF) titer results in serial specimens are considered diagnostic of active disease.

 

Immunodiffusion:

The presence of IgM antibodies may be detectable within 2 weeks after the onset of symptoms; however, the antibody may be detected longer than 6 months after infection.

 

The presence of IgG antibodies parallels the CF antibodies and may suggest an active or a recent asymptomatic infection with Coccidioides immitis/posadasii; however, antibodies may persist after the infection has resolved.

 

An equivocal result (a band of nonidentity) cannot be interpreted as significant for a specific diagnosis. However, this may be an indication that a patient should be followed serologically.

 

Over 90% of primary symptomatic cases will be detected by combined immunodiffusion and CF testing.

Report Available

4 to 7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Method Name

Complement Fixation (CF)/Immunodiffusion (ID)

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.