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HelpTest Code SIL2R Interleukin-2 Receptor Alpha soluble, Plasma
Ordering Guidance
If this test is ordered with CYPAN / Cytokine Panel, Plasma, this test will be canceled as duplicate and CYPAN performed as ordered.
If this test is ordered with CYTH1 / T-Helper Cell Type 1 Cytokine Panel, Plasma, this test will be canceled as duplicate and CYTH1 performed as ordered.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Lavender-top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Immediately after specimen collection, place tube on wet ice.
2. Centrifuge at 4° C, 1500 x g for 10 minutes.
3. Aliquot plasma into plastic vial.
4. Freeze specimen within 2 hours of collection.
Additional Information:
If a refrigerated centrifuge is not available, it is acceptable to use a room temperature centrifuge, provided the sample is kept on ice before centrifugation and is frozen immediately afterward.
Useful For
Measuring the concentration of soluble interleukin-2 receptor alpha (sIL-2r alpha) in plasma
Aids in the diagnosis and evaluation of patients for lymphoproliferative disorders, including autoimmune lymphoproliferative syndrome, hemophagocytic lymphohistiocytosis, and macrophage activation syndrome
May help monitor patients with sarcoidosis or hematologic malignancies with elevated sIL-2r alpha
Method Name
Bead-Based Multiplex Immunoassay
Reporting Name
IL-2 receptor alpha soluble, PSpecimen Type
Plasma EDTASpecimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma EDTA | Frozen | 21 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
| Heat-treated specimen | Reject |
Reference Values
<18 years: Not established
≥18 years: <959 pg/mL
Interpretation
A significant elevation in soluble interleukin-2 receptor alpha (sIL-2r alpha) concentration (2SD above age-adjusted laboratory-specific reference range) is one of the diagnostic criteria for hemophagocytic lymphohistiocytosis (HLH) syndrome. The diagnosis of HLH syndrome should be based on compatible clinical presentation in the context of significantly elevated inflammatory markers, including ferritin, sIL-2r alpha, and CXCL9 (C-X-C motif chemokine ligand 9).
Day(s) Performed
Thursday
Report Available
2 to 8 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83520
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SIL2R | IL-2 receptor alpha soluble, P | 76039-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 622328 | IL-2 receptor alpha soluble | 76039-7 |