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Test Code SLA Soluble Liver Antigen (SLA) IgG Antibodies, Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL Serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Forms

If not ordering electronically, complete, print, and send Gastroenterology and Hepatology Test Request (T728) with the specimen.

Useful For

Evaluation of patients at-risk for autoimmune hepatitis or liver disease of unknown etiology

Testing Algorithm

For information see First-Line Screening for Autoimmune Liver Disease Algorithm.

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Soluble Liver Antigen Ab, IgG, S

Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK
Heat treated specimens Reject

Reference Values

Negative: <20.0 U

Equivocal: 20.0-24.9 U

Positive: ≥ 25.0 U

Interpretation

A positive anti-SLA (soluble liver antigen) antibody test is highly specific marker for autoimmune hepatitis (AIH), especially in cases where other antibodies are absent. It occurs in approximately 10% to 30% of patients with AIH.

Day(s) Performed

Monday

Report Available

2 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83516

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SLA Soluble Liver Antigen Ab, IgG, S 32219-8

 

Result ID Test Result Name Result LOINC Value
SLA Soluble Liver Antigen Ab, IgG, S 32219-8