Test Code TOBRA Tobramycin, Random, Serum
Useful For
Monitoring adequacy of serum concentration during tobramycin therapy
This unit code is used whenever a specimen is submitted or collected without collection timing information. The phlebotomist should use this unit code if she or he does not know if this is a peak or trough specimen.
Method Name
Immunoassay
Reporting Name
Tobramycin, Random, SSpecimen Type
SerumOrdering Guidance
Serum for a peak level should be drawn 30 to 60 minutes after last dose (order TOBPA / Tobramycin, Peak, Serum).
Serum for a trough level should be drawn no more than 30 minutes before next scheduled dose (order TOBTA / Tobramycin, Trough, Serum).
Specimen Required
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL
Collection Instructions:
1. Serum gel tubes should be centrifuged within 2 hours of collection.
2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.
Specimen Minimum Volume
0.25 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 7 days | |
Frozen | 28 days | ||
Ambient | 72 hours |
Reject Due To
Gross hemolysis | Reject |
Reference Values
TOBRAMYCIN, PEAK
Therapeutic: 3.0-12.0 mcg/mL
Toxic: >12.0 mcg/mL
TOBRAMYCIN, TROUGH
Therapeutic: <2.0 mcg/mL
Toxic: >2.0 mcg/mL
Interpretation
Target peak concentrations depend on the type of infection being treated. Goal trough levels should be below 2.0 mcg/mL. Concentrations refer to conventional (non-pulse) dosing. Prolonged exposure to either peak levels exceeding 12.0 mcg/mL or trough levels exceeding 2.0 mcg/mL may lead to toxicity.
Day(s) Performed
Monday through Sunday
Report Available
Same day/1 to 2 daysPerforming Laboratory
Mayo Clinic Laboratories in RochesterLOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
TOBRA | Tobramycin, Random, S | 35670-9 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
TOBRA | Tobramycin, Random, S | 35670-9 |
CPT Code Information
80200
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.