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Test Code TOBRA Tobramycin, Random, Serum

Useful For

Monitoring adequacy of serum concentration during tobramycin therapy

 

This unit code is used whenever a specimen is submitted or collected without collection timing information. The phlebotomist should use this unit code if she or he does not know if this is a peak or trough specimen.

Method Name

Immunoassay

Reporting Name

Tobramycin, Random, S

Specimen Type

Serum


Ordering Guidance


Serum for a peak level should be drawn 30 to 60 minutes after last dose (order TOBPA / Tobramycin, Peak, Serum).

 

Serum for a trough level should be drawn no more than 30 minutes before next scheduled dose (order TOBTA / Tobramycin, Trough, Serum).



Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject

Reference Values

TOBRAMYCIN, PEAK

Therapeutic: 3.0-12.0 mcg/mL

Toxic: >12.0 mcg/mL

 

TOBRAMYCIN, TROUGH

Therapeutic: <2.0 mcg/mL

Toxic: >2.0 mcg/mL

Interpretation

Target peak concentrations depend on the type of infection being treated. Goal trough levels should be below 2.0 mcg/mL. Concentrations refer to conventional (non-pulse) dosing. Prolonged exposure to either peak levels exceeding 12.0 mcg/mL or trough levels exceeding 2.0 mcg/mL may lead to toxicity.

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TOBRA Tobramycin, Random, S 35670-9

 

Result ID Test Result Name Result LOINC Value
TOBRA Tobramycin, Random, S 35670-9

CPT Code Information

80200 

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.